ƒPublications„

1)Y. Shirosaki, C.M. Botelho, M.A. Lopes, J.D. Santos, "Synthesis and characterization of chitosan-silicate hydrogel as resorbable vehicle for Bonelike® bone graft", Journal of Nanoscience and Nanotechnology, 9[6], 3714-3719 (2009).

2)Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, M.A. Lopes, J.D. Santos, M.A. Costa, M.H. Fernandes, "Physical, chemical and in vitro biological profile of chitosan hybrids membrane as a function of organosiloxane concentration", Acta Biomaterialia, 5[1], 346-355 (2009).

3)S. Chen, A. Osaka, S. Hayakawa, Y. Shirosaki, E. Fujii, K. Kawabata, K. Tsuru, "Structure and morphology of aminopropyltriethoxysilane-modified TiO2 nano-particles derived from sol-gel processing of tetraethylorthotitanate", Journal of the Ceramic Society of Japan, 117[4], 537-541 (2009).

4)T. Shozui, K. Tsuru, S. Hayakawa, Y. Shirosaki, A. Osaka, "XPS study on potential suppression factors of suppressing in vitro apatite formation on anatase films prepared on various substrates", Surface & Coating Technology, 203[16], 2181-2185 (2009).

5)S. Chen, S. Hayakawa, Y. Shirosaki, E. Fujii, K. Kawabata, K. Tsuru, A. Osaka, "Sol-gel synthesis and microstructure analysis of amino-modified hybrid silica nanoparticles from aminopropyltriethoxysilane and tetraethoxysilane", Journal of American Ceramic Society, 92[9], 2074-2082 (2009).

6)D. Boyd, S. Murphy, M.R. Towler, A.W. Wren, S. Hayakawa, "Analysis of gamma-irradiated synthetic bone grafts by 29Si MAS-NMR spectroscopy", Journal of Non-Crystalline Solids, 355[45-47], 2285-2288 (2009).

7)K. Gotoh, T. Ueda, T. Eguchi, K. Kawabata, K. Yamamoto, Y. Murakami, S. Hayakawa, H Ishida", Pore structure of hard carbon made from phenolic resin studyed by Xe-129 NMR", Bulletin of the Chemical Society of Japan, 82[10], 1232-1239 (2009).

8)S. Barheine, S. Hayakawa, A. Osaka, C. Jaeger", Surface, interface and bulk strucure of borate containing apatitic biomaterials", Chemistry of Materials, 21[14], 3102-3109 (2009).

9)T. Uchino, C. Ohtsuki, M. Kamitakahara, T. Miyazaki, S. Hayakawa, A. Osaka", Synthesis of bioactive HEMA-MPS-CaCl2 hybrid gels: effects of catalysts in the sol-gel processing on mechanical properties and in vitro hydroxyapatite formation in a simulated body fluid", Journal of Biomaterials Applications, 23[6], 519-532 (2009).

10)S. Hayakawa, Y. Li, K. Tsuru, A. Osaka, E. Fujii, K. Kawabata!, Preparation of nanometer-scale rod array of hydroxyapatite crystal!, Acta Biomaterialia, 5[6], 2152-2160 (2009).

11)A. Sugino, K. Tsuru, S. Hayakawa, K. Kikuta, G. Kawachi, A. Osaka, C. Ohtsuki", Induced deposition of bone-like hydroxyapatite on thermally oxidized titanium substrates using a spatial gap in a solution that mimics a body fluid", Journal of the Ceramic Society of Japan, 117[4], 515-520 (2009).

12)A. Sugino, C. Ohtsuki, K. Tsuru, S. Hayakawa, T. Nakano, Y. Okazaki, A. Osaka", Effect of spatial design and thermal oxidation on apatite formation on Ti-15Zr-4Ta-4Nb alloy", Acta Biomaterialia, 5[1], 298-304 (2009).

ƒProceedings„

1)Y. Shirosaki, M.A. Lopes, J.D. Santos, K. Tsuru, S. Hayakawa, A. Osaka, A.C. Mauricio, S. Geuna,"Nerve regeneration guided by chitosan hybrid membranes", Archives of Bio Ceramics Research, Vol.9, pp.147-150, (2009).

2)A. Sugino, K. Uetsuki, Y. Shirosaki, S. Hayakawa, K. Tsuru, C. Ohtsuki, A. Osaka", GRAPE® technology improves apatite-formation on thermally derived titania layer", Archives of Bio Ceramics Research, Vol.9, pp.175-178, (2009).

3)Y. Nakao, A. Sugino, K. Tsuru, K. Uetsuki, Y. Shirosaki, S. Hayakawa, A. Osaka, "Apatite-forming ability on spatial design enhanced y autoclaving", Archives of Bio Ceramics Research, Vol.9, pp.387-390, (2009).

4)A. Osaka, Y.Shirosaki, K. Tsuru, S. Hayakawa", Preparation of chtiosan-silicate hybrid to induce osteodifferentiation of human bone marrow cells", The 26th International Japan-Korea Seminar on Ceramics, Extended abstracts, 2E-08, pp.417-418, (2009).

5)A. Ito, Y. Sogo, A. Yamazaki, M. Aizawa, A. Osaka, S. Hayakawa, M. Kikuchi, I. Akahane, K. Yamashita, Y. Tanaka, M. Tadokoro, H. Ohgushi, "In vitro method to characterize resorption of calcium phosphate-based ceramic scafolds", The 26th International Japan-Korea Seminar on Ceramics, Extended abstracts, 2E-11, pp.425-428, (2009).

6)S. Hayakawa, Y. Li, Y. Shirosaki, A. Osaka, E. Fujii, K. Kawabata, "A novel method of preparing a nano-meter rod array of hydroxypaatite crystals", Bioceramics, Vo. 22, ed. S. Kim, The Korean Society for Biomaterials, pp.89-92, (2009).

7)Y. Shirosaki, K. Tsuru, S. Hayakawa, Y. Nakamura, I.R. Gibson, A. Osaka, "Effect of Si(IV) released from chitosan-silicate hybrids on proliferation and differentiation of MG63 osteoblastic cells", Bioceramics, Vo. 22, ed. S. Kim, The Korean Society for Biomaterials, pp.217-220, (2009).

8)K. Uetsuki, Y. Shirosaki, S. Hayakawa, A. Osaka, "Contrary effects of UV-irradiatio on in vitro apatite-forming ability of TiO2 layer in simulated body fluid", Bioceramics, Vo. 22, ed. S. Kim, The Korean Society for Biomaterials, pp.341-344, (2009).

9)Y. Li, N. Hirota, M. Okuda, S. Chen, M. Tagaya, Y. Shirosaki, S. Hayakawa, A. Osaka, N. Hanagata, T. Ikoma, "Viscoelastic property of collagen gels with aligned fibril structure", Bioceramics, Vo. 22, ed. S. Kim, The Korean Society for Biomaterials, pp.661-664, (2009).

10)S. Barheine, S. Hayakawa, A. Osaka, C Jaeger, "A NMR investigation of borate incorporation in apatitic biomaterials", Key Engineering Materials, Vols.396-398, pp.205-208, (2009).

ƒInternational Congress„

1)S. Chen, S. Hayakawa, K. Tsuru, Y. Shirosaki, A. Osaka, "Self-catalyzed synthesis of amino-modified silica nanoparticles", First International Conference on Multifunctional, Hybrid and Nanomaterials, Hybrids Materials 2009, 2009.3 15-19, Tours, France.

2)S. Hayakawa, K. Tsuru, A. Matsumoto, E. Fujii, K. Kawabata, A. Osaka, "Synthesis and characterization of wet-chemically derived magnetite-HAp hybrid nanoparticles", 33rd International Conference and Exposition on Advanced Ceramics and Composites, Symposium 5: Next Generation Bioceramics, ICACC-S5-001-2009, 2009.1.18-23, Florida, USA.

3)S. Chen, S. Hayakawa, K. Tsuru, A. Osaka, "One-step preparation of organosiloxane-derived silica particles", 33rd International Conference and Exposition on Advanced Ceramics and Composites, Symposium 5: Next Generation Bioceramics, Invited, ICACC-S5-006-2009, 2009.1.18-23, Florida, USA.

4)Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, K. Kataoka, K. Deguchi, H. Zhang, N.H. Hu, K. Abe, "Organic-inorganic hybrids scaffolds for cell culture and tissue regeneration", 8th Pacific Rim Conference on Ceramic and Glass Technology, Symposium 21: Nano-Biotechnology and Ceramics in Biomedical Application, PACRIM8-S21-O11-2009, p.34, 2009.5.31-6.5, British Columbia, Canada.

5)E. Fujii, K. Kawabata, Y. Nakazaki, Y. Tanizawa, A. Matsumoto, Y. Shirosaki, S. Hayakawa, A. Osaka, "Preration of hydroxyaatite nano particles applying micro chemical processes", 8th Pacific Rim Conference on Ceramic and Glass Technology, Symposium 21: Nano-Biotechnology and Ceramics in Biomedical Application, Invited, PACRIM8-S21-P166-2009, p.96, 2009.5.31-6.5, British Columbia, Canada.

6)S, Hayakawa, K. Kawanishi, K. Tsuru, Y. Shirosaki, A. Osaka, "Cell proliferation on nano-structured titanium oxide layer prepared on titanium substrates", 8th Pacific Rim Conference on Ceramic and Glass Technology, PACRIM8-S21-O29-2009, p.118, 2009.5.31-6.5, British Columbia, Canada.

7)K. Uetsuki, H. Kaneda, Y. Shirosaki, S. Hayakawa, A. Osaka, "Effects of UV-irradiation on in vitro apatite-forming ability of TiO2 layers", 3rd International Conference on Science and technology for Advanced Ceramics (STAC3), p.164, 2009.6.16-18, Yokohama, Japan.

8)Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, "Ceramic nano-particles for biomedical applications", The Sixth China International Conference on High-Performance ceramics, SD, Bioceramics, Invited, D1-001, 2009.8.16-19, Harbin, Chaina.

9)Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, "Injectable chitosan-silicate hydrogels for bone-repair", XV International Sol-Gel Conference, sol-gel'09, OS9-06, p.99, 2009.8.23-27, Porto de Glinhas, Brazil.

10)A. Sugino, K. Tsuru, S. Hayakawa, Y. Shirosaki, A. Osaka, C. Ohtsuki, "Osteoconductivity of Ti-15Zr-4Nb-4Ta alloy modified with GRAPE technology", 22nd European Conference on Biomaterials, The annual conference of the European Society for Biomaterials, 2009.9.7-11, Lausanne, Switzerland.

11)S. Hayakawa, Y. Li, Y. Shirosaki, A. Osaka, E. Fujii, K. Kawabata, "A novel method of preparing a nanometer-scale rod array of hydroxyapatite crystals", The 22nd International Symposium on Ceramics in Medicine, Bioceramics 22, pp.89-92, 2009.10.26-29, Daegu, Korea.

12)Y. Shirosaki, K. Tsuru, S. Hayakawa, Y. Nakamura, I.R. Gibson, A. Osaka, "Effects of Si(IV) released from chitosan-silicate hybrids on proliferation and differentiation of MG63 osteoblast cells", The 22nd International Symposium on Ceramics in Medicine, Bioceramics 22, pp.217-220, 2009.10.26-29, Daegu, Korea.

13)K. Uetsuki, Y. Shirosaki, S. Hayakawa, A. Osaka, "Contrary effects of UV-irradiation on in vitro apatite-forming ability of TiO2 layer in simulated body fluid", The 22nd International Symposium on Ceramics in Medicine, Bioceramics 22, pp.341-344, 2009.10.26-29, Daegu, Korea.

14)Y. Li, N. Hirota, M. Okuda, S. Chen, M. Tagaya, Y. Shirosaki, S .Hayakawa, A. Osaka, N. Hanagata, T. Ikoma, "Viscoelastic property of collagen gels with aligned fibrill structure", The 22nd International Symposium on Ceramics in Medicine, Bioceramics 22, pp.661-664, 2009.10.26-29, Daegu, Korea.

15)A. Osaka, Y. Shirosaki, K. Tsuru, S. Hayakawa, "Preparation of chitosan-silicate hybrid to introduce osteodifferentiation of human bone marrow cells", The 26th International Japan-Korea Seminar on Ceramics, 2E-08, 2009.11.24-26, Tsukuba, Japan.

16) Y. Shirosaki, M.A. Lopes, J.D. Santos, K. Tsuru, S. Hayakawa, A. Osaka, A.C. Mauricio, S. Geuna, "Nerve regeneration guided by chitosan hybrid membranes", Special Symposium for Celebration on the 10th Anniversary of the Division of Ceramics in Medicine, Biology and Biomimetics, The Ceramic Society of Japan in conjunction with 9th Asian Bioceraics Symposium (ABC2009), O-31, 2009.12.8-11, Nagoya, Japan.

17)A. Sugino, K. Uetsuki, Y. Shirosaki, S. Hayakawa, K. Tsuru, C. Ohtsuki, A. Osaka, "GRAPE® Technology improves apatite-formation on thermally derived titania layer", Special Symposium for Celebration on the 10th Anniversary of the Division of Ceramics in Medicine, Biology and Biomimetics, The Ceramic Society of Japan in conjunction with 9th Asian Bioceraics Symposium (ABC2009), O-38, 2009.12.8-11, Nagoya, Japan.

18)Y. Nakao, A. Sugino, K. Tsuru, K. Uetsuki, Y. Shirosaki, S. Hayakawa, A. Osaka, "Apatite-forming ability on spatial design enhanced by autoclaving", Special Symposium for Celebration on the 10th Anniversary of the Division of Ceramics in Medicine, Biology and Biomimetics, The Ceramic Society of Japan in conjunction with 9th Asian Bioceraics Symposium (ABC2009), P-56, 2009.12.8-11, Nagoya, Japan.