1)X-X. Wang, W. Yan, S. Hayakawa, K. Tsuru, A. Osaka, "Apatite deposition on thermally and anodically oxidized titanium surfaces in a simulated body fluid", Biomaterials, 24[25], 4631-4637 (2003).

2)I. Yamaguchi, T. Kogure, M. Sakane, S. Tanaka, A. Osaka, J. Tanaka, "Microstructure analysis of calcium phosphate formed in tendon", Journal of Materials Science: Materials in Medicine, 14, 883-889 (2003).

3)J-M. Wu, F. Xiao, S. Hayakawa, K. Tsuru, S. Takemoto, A. Osaka, "Bioactivity of metallic biomaterials with anatase layers deposited in acidic titanium tetrafluoride solution", Journal of Materials Science: Materials in Medicine, 14[12],1027-1032 (2003).

4)F. Xiao, K. Tsuru, S. Hayakawa, A. Osaka, "In vitro apatite deposition on titania film derived from chemical treatment of Ti substrates with an oxysulfate solution containing hydrogen peroxide at low temperature", Thin Solid Films, 441[1-2], 271-276 (2003).

5)Y. Aburatani, K. Tsuru, S. Hayakawa, A. Osaka, "Mechanical property and microstructure of bioactive organic-inorganic hybrids containing colloidal silica particles", Journal of the Ceramic Society of Japan, 111[4], 247-251 (2003).

6)Y. Aburatani, K. Tsuru, S. Hayakawa, A. Osaka, "Bioactivity of viscoelastic ormosil-type organic-inorganic hybrids containig colloidal silica particles", Journal of the Ceramic Society of Japan, 111[5], 318-322 (2003).

7)T. Asano, S. Takemoto, K. Tsuru, S. Hayakawa, A. Osaka, S. Takashima, "Sol-gel preparation of blood-compatible titania as an adsorbent of bilirubin", Journal of the Ceramic Society of Japan, 111[9], 645-650 (2003).

8)E. Fujii, K. Kawabata, H. Yoshimatsu, S. Hayakawa, K. Tsuru, A. Osaka, "Structure and biomineralization of calcium silicate glasses containing fluoride ions", Journal of the Ceramic Society of Japan, 111[10], 762-766 (2003).

9)T. Yoshioka, K. Tsuru, S. Hayakawa, A. Osaka, "Preparation of alginic acid layers on stainless-steel substrates for biomedical applications", Biomaterials, 24[17], 2889-2894 (2003).

10)T. Kim, M. Suzuki, C. Ohtsuki, K. Masuda, H. Tamai, E. Watanabe, A. Osaka, H. Moriya, "Enhancement of bone growth in titanium fiber mesh by surface modification with hydrogen peroxide solution containing tantalum chloride", Journal of Biomedical Materials Research Part B: Applied Biomaterials, 64B, 19-26 (2003).

11)J-M. Wu, S. Hayakawa, K. Tsuru, A. Osaka, "Early apatite deposition on titanium treated by hydrogen peroxide", Journal of Australian Ceramic Society, 39[1], 36-42 (2003).

12)I. Yamaguchi, S. Itoh, M. Suzuki, M. Sakane, A. Osaka, J. Tanaka, "The chitosan prepared from crab tendon I: the characterization and the mechanical properties", Biomaterials, 24[12], 2031-2036 (2003).

13)I. Yamaguchi, S. Itoh, M. Suzuki, A. Osaka, J. Tanaka, "The chitosan prepared from crab tendons: II. The chitosan/apatite composites and their application to nerve regeneration", Biomaterials, 24[19], 3285-3292 (2003).

14)I. Yamaguchi, S. Iizuka, A. Osaka, H. Monma, J. Tanaka, "The effect of citric acid addition on chitosan/hydroxyapatite composites", Colloids and Surfaces A: Physicochemical and Engineering Aspects, 214[1-3], 111-118 (2003).

15)A. Mori, I. Sakuramoto, E. Watanabe, K. Nagata, A. Osaka, K. Kuramoto, "Effects of manufacturing conditions on the oxidation resistance of directly molded UHMWPE", Journal of Japanese Society for Biomaterials, 21, 311-318 (2003).

16)森亜希子，富田直秀，金枝敏明，渡辺英一郎，永田員也，尾坂明義，蔵本孝一，"ビタミンE添加UHMWPE材料の疲労特性−人工関節におけるlift-offを考慮して−"，バイオマテリアル−生体材料−，21, 64-70 (2003).

17)A. Mori, C. Ohtsuki, A. Sugino, K. Kuramoto, T. Miyazaki, M. Tanihara, A. Osaka, "Bioactive PMMA-based bone cement modified with methacryloxypropyl-trimethoxysilane and calcium salts: Effects of calcium salts on apatite-forming ability", Journal of the Ceramic Society of Japan, 111, 738-742 (2003).

18)T. Yabuta, E.P. Bescger, J.D. Mackenzie, K. Tsuru, S. Hayakawa, C. Ohtsuki, A. Osaka, "Synthesis of PDMS-based porous materials for biomedical applications", Journal of Sol-Gel Science and Technology, 26[1-3], 1219-1222 (2003).

19)L. Ren, K. Tsuru, S. Hayakawa, A. Osaka, "In vitro evaluation of osteoblast response to Sol-Gel derived gelatin-siloxane hybrids", Journal of Sol-Gel Science and Technology, 26[1-3], 1137-1140 (2003).

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＜Proceedings＞

1)S. Hayakawa, K. Shibata, K. Tsuru, A. Osaka, "Bioactive titania gel derived from combined chemical and thermal treatments of titanium", Ceramic Engineering and Science Proceedings, 27th International Cocoa Beach Conference on Advanced Ceramics and Composites: A , Vol. 24, Issue 3, ed. W. M. Kriven, H-T. Lin, pp. 227-232 (2003).

2)T. Ogawa, K. Tsuru, S. Hayakawa, S. Takashima, A. Osaka, "Effects of metals on generation and dismutation of active oxygen species in blood", Archives of BioCeramics Research, Vol. 3, ed. M. Okazaki, K. Ishikawa, K. Yamashita, Y. Doi, S. Ban, pp. 336-341 (2003).

3)S. Hayakawa, K. Tsuru, A. Osaka, "Platelet adhesion on titania film prepared from interaction of Ni-Ti alloy with hydrogen peroxide solution", in Bioceramics, Vol. 16, ed. M.A. Barbosa, F. J. Monteiro, R. Correia, B. Leon, Trans Tech Publications, pp. 865-868 (2003).

4)Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, M. A. Lopes, J. D. Santos, M. H. Fernandes, "In vitro cytocompatibility of osteoblastic cells cultured on chitosan-organosiloxane hybrid membrane", in Bioceramics, Vol. 16, ed. M.A. Barbosa, F. J. Monteiro, R. Correia, B. Leon, Trans Tech Publications, pp. 857-860 (2003).

5)S. Takemoto, T. Yamamoto, K. Tsuru, S. Hayakawa, A. Osaka, "Platelet adhesion on metal oxide layers", in Bioceramics, Vol. 16, ed. M.A. Barbosa, F. J. Monteiro, R. Correia, B. Leon, Trans Tech Publications, pp. 853-856 (2003).

6)S. Kawasaki, K. Tsuru, S. Hayakawa, A. Osaka, "Control of morphology of titania film with high apatite-forming ability derived from chemical treatments of titanium with hydrogen peroxide", in Bioceramics, Vol. 16, ed. M.A. Barbosa, F. J. Monteiro, R. Correia, B. Leon, Trans Tech Publications, pp. 443-446 (2003).

7)T. Yoshioka, K. Tsuru, S. Hayakawa, A. Osaka, "Blood compatibility of stainless-steel and titanium immobilized with alginic acid layers", Materials Research Society Symposium Proceeding, Vol. 734, pp.333-338 (2003).

8)K. Tsuru, S. Takemoto, T. Yamamoto, S. Hayakawa, A. Osaka, S. Takashima, "Blood compatibility of metal oxide layers on stainless-steel", Materials Research Society Symposium Proceeding, Vol. 734, pp.327-332 (2003).

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＜International Congress＞

1)Y. Kuboki, R. Yoshimoto, N. Tanaka, H. Takita, K. Tsuru, A. Osaka, A. Yanagisawa, M. Kaneko, K. Nemoto, T. Miyata, "Geometry of artificial extracellular matrix: Creation of three-dimensional bonding between bone and titanium by the web of 50-microns titanium fibers", Bone, 32[5], pp. S194-S194, (2003). Meeting Abstract.

2)Y. Kuboki, R. Yoshimoto, N. Tanaka, H. Uramoto Y., Takita, K. Tsuru, A. Osaka, M. Kaneko, A. Yanagisawa, K. Nemoto, T. Miyata, "Web of fine titanium fibers created a three-dimensional bonding between bone and titanium by the geometry of artificial ECM", Journal of Dental Research, 82, Sp. Iss. B, pp. B277-B277, (2003). Meeting Abstract.

3)S. Hayakawa, A. Osaka, K. Shibata, K. Tsuru, "Bioactive titania gel-derived from combined chemical and thermal treatments of titanium", The 27th Annual Cocoa Beach Conference & Exposition on Advanced Ceramics & Composites, 2003.1.29-30, Cocoa Beach, U.S.A.

4)Y. Kusudo, K. Tsuru, S. Hayakawa, S. Takashima, A. Osaka, "Hydroxy-carbonate apatite: synthesis, blood compatibility and adsorption of specific pathogenic proteins", The ACerS 105th Annual Meeting and Exposition, Abstract AM-S2-29-2003, p. 10, 2003.4.28-29, Nashville, U.S.A.

5)Y. Higashi, K. Tsuru, S. Hayakawa, A. Osaka, "Effects of organic molecules in the Kokubo's simulated body fluid on apatite formation on bioactive glass and titanium substrates", The ACerS 105th Annual Meeting and Exposition, Abstract AM-S2-7-2003, 2003.4.28-29, Nashville, U.S.A.

6)T. Yabuta, K. Tsuru, S. Hayakawa, A. Osaka, "Synthesis of blood compatible PDMS-based organic-inorganic hybrid coatings", 12th International Workshop on Sol-Gel Science and Technology, Abstract 743, p. 240, 2003.8.24-29, Sydney, Australia.

7)A. Osaka, K. Tsuru, S. Hayakawa, "Synthesis of bioactive and porous organic-inorganic hybrids and their biomedical application", 12th International Workshop on Sol-Gel Science and Technology, Abstract I12, p. 58, 2003.8.24-29, Sydney, Australia.

8)K. Tsuru, Y. Shirosaki, S. Hayakawa, A. Osaka, "In vitro biological reactivity of chitosan-organosiloxane hybrid", European Congress and Exhibition on Advanced Materials and Processes (EUROMAT2003), Symposium C3, Session: Bio-Active and Bio-Hybrid materials, Programme p. 28, 2003.09.02, Switzerland, Lausanne.

9)E. Fujii, K. Kawabata, H. Yoshimatsu, K. Tsuru, S. Hayakawa, A. Osaka, "Preparation and properties of hydroxyapatite powder with metal alkoxide", The 5th International
Meeting of Pacific Rim Ceramic Societies, Abstract aa-P-03, p. 171, 2003.9.30, Nagoya, Japan.

8)S. Hayakawa, K. Tsuru, Y. Higashi, A. Osaka, "Apatite formation on bioactive glass and titanium substrate in the Kokubo's simulated body fluid containing organic molecules", The 5th International Meeting of Pacific Rim Ceramic Societies, Abstract 11-O-05, p. 164, 2003.9.30, Nagoya, Japan.

9)K. Tsuru, T. Yamamoto, Y. Yamane, S. Hayakawa, A. Osaka, "Blood compatibility of Sol-Gel derived metal oxide layers", The 5th International Meeting of Pacific Rim Ceramic
Societies, Abstract 11-O-20, p. 168, 2003.10.1, Nagoya, Japan.

10)T. Yamamoto, A. Osaka, S. Hayakawa, K. Tsuru, S. Takashima, "Blood compatibility of titanium oxide layer prepared by chemical and heat treatments", The 5th International
Meeting of Pacific Rim Ceramic Societies, Abstract 11-P-21, p. 176, 2003.10.1, Nagoya, Japan.

11)A. Osaka, S. Takemoto, K. Tsuru, S. Hayakawa, S. Takashima, "Blood-compatible titania and carbonate apatite for selective adsorption of protains", The 5th International Meeting of Pacific Rim Ceramic Societies, Abstract 11-I-05, p. 163, 2003.10.1, Nagoya, Japan.

12)A. Osaka, K. Tsuru, S. Hayakawa, "Porous organic - inorganic hybrids for tissue engineering application", The 8th IUMRS International Conference on Advanced Materials, C9-12-O11, 2003.10.12, Yokohama, Japan.

13)T. Yoshioka, K. Tsuru, S. Hayakawa, A. Osaka, "In vitro platelet adhesion and protein adsorption of biomedical implant modified with polysaccharide", The 8th IUMRS International Conference on Advanced Materials, C4-13-P06, 2003.10.13, Yokohama, Japan.

14)N. Azuma, T. Ikoma, A. Osaka, J. Tanaka, "Novel hydrogels of malic acid and zinc: Synthesis and characterization", The 8th IUMRS International Conference on Advanced Materials, C9-12-O13, 2003.10.13, Yokohama, Japan.

15)A. Osaka, T. Yoshioka, T. Yabuta, K. Tsuru, S. Hayakawa, "Anti-blood clotting behavior of metal implants hybridized with organic or inorganic coating", Composites at Lake
Louise 2003, 2003.10.22, Lake Louise, Canada.

16)S. Hayakawa, K. Tsuru, A. Osaka, "Platelet adhesion on titania film prepared from interaction of Ni-Ti alloy with hydrogen peroxide solution", The 16th International Symposium on Ceramics in Medicine, Bioceramics, Vol.16, 2003.11.08, Porto, Portugal.

17)S. Takemoto, T. Yamamoto, K. Tsuru, S. Hayakawa, A. Osaka, "Platelet adhesion on metal oxide layers", The 16th International Symposium on Ceramics in Medicine, Bioceramics, Vol.16, 2003.11.08, Porto, Portugal.

18)S. Kawasaki, K. Tsuru, S. Hayakawa, A. Osaka, "Control of morphology of titania film with high apatite-forming ability derived From chemical treatments of titanium with hydrogen peroxide", The 16th International Symposium on Ceramics in Medicine, Bioceramics, Vol.16, 2003.11.08, Porto, Portugal.

19)Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, M.A. Lopes, J.D. Santos, M.H. Fernandes, "In vitro cytocompatibility of osteoblastic cells cultured on chitosan-organosiloxane hybrid membrane", The 16th International Symposium on Ceramics in Medicine, Bioceramics, Vol.16, 2003.11.08, Porto, Portugal.

20)T. Ogawa, K. Tsuru, S. Hayakawa, S. Takashima, A. Osaka, "Effect of metals on generation and dismutation of active oxygen species in blood", The 3nd Asian BioCeramics Symposium (ABC2003), Proc. pp. 336-341, 2003.11.20, Fukuoka, Japan.

21)Y. Liu , K. Tsuru, S. Hayakawa, A. Osaka, "Titanate nano-rods grown on titanium substrates", The 20th International Japan-Korea Seminar on Ceramics, pp. 299-302, 2003.11.20-22, Matsue, Japan.

22)N. Azuma, T. Ikoma, A. Osaka, J. Tanaka, "Novel malic acid-zinc hydrogels", The MRS International Conference fall meeting 2003, Abstract K7-22, p. 145, 2003.12.3, Boston, USA.