<特許>

1)A. Osaka, S. Hayakawa, K. Tsuru, K. Koyano, K. Ohta, "Biocompatible titanium implant for medical use", US2002-0143398A1, 2002年10月3日


<著書・総説>

1)A. Osaka, S. Hayakawa, K. Tsuru, "Biomimetic Apatite Coating on Chemically and Electrochemically Treated Titanium", in Biomimetic Calcium Phosphate Coatings 2002, ed. Hai Bo Wen, Research Signpost, ISBN81-7736-090-6, pp. 1-13, 2002年


<研究論文>

1)X.-X. Wang, S. Hayakawa, K. Tsuru, A. Osaka, "Bioactive titania gel layers formed by chemical treatment of Ti substrate with a H2O2/HCl solution", Biomaterials, 23[5], 1353-1357 (2002).

2)J.-M. Wu, S. Hayakawa, K. Tsuru, A. Osaka, "Crystallization of anatase from amorphous titania in hot water and in vitro biomineralization", Journal of The Ceramic Society of Japan, 110, 78-80 (2002).

3)J.-M. Wu, S. Hayakawa, K. Tsuru, A. Osaka, "Nanocrystalline titania made from interactions of Ti with hydrogen peroxide solutions containing tantalum chloride", Crystal Growth&Design, 2[2], 147-149 (2002).

4)J.-M. Wu, S. Hayakawa, K. Tsuru, A. Osaka, "Soft solution approach to prepare crystalline titania films", Scripta Materialia, 46[10], 705-709 (2002).

5)J.-M. Wu, S. Hayakawa, K. Tsuru, A. Osaka, "Porous titania films prepared from interactions of titanium with hydrogen peroxide solution", Scripta Materialia, 46[1], 101-106 (2002).

6)Y. Aburatani, K. Tsuru, S. Hayakawa, A. Osaka, "Mechanical properties and microstructure of bioactive ORMISILs containing silica particles", Materials Science and Engineering C, 20[1-2], 195-198 (2002).

7)J.M. Wu, S. Hayakawa, K. Tsuru, A. Osaka, "In vitro bioactivity of anatase film obtained by direct deposition from aqueous titanium tetrafluoride solutions", Thin Solid Films, 414[2], 275-280 (2002).

8)L. Ren, K. Tsuru, S. Hayakawa, A. Osaka, "Novel approach to fabricate porous gelatin-siloxane hybrids for bone tissue engineering", Biomaterials, 23[24], 4765-4773 (2002).


<国際学会プロシーディングス>

1)S. Hayakawa, A. Osaka, "29Si NMR study of divalent metal oxyfluorosilicate glass", Physics and Chemistry of Glasses, Vol. 43C, Optical, opto-electronics, nano and coloured glasses, pp. 224-227 (2002).

2)K. Tsuru, S. Hayakawa, C. Ohtsuki, A. Osaka, "In vitro bioactivity and structure of alkali borosilicate glasses", Physics and Chemistry of Glasses, Vol. 43C, 326-329 (2002).

3)Y. Aburatani, K. Tsuru, S. Hayakawa, A. Osaka, "Heating effect on properties of organic-inorganic hybrids containing colloidal silica particles", Key Engineering and Materials, Vols. 218-220, 445-448 (2002).

4)S. Takashima, Y. Kusudo, S. Takemoto, K. Tsuru, S. Hayakawa, A. Osaka, "Synthesis of carbonate-hydroxy apatite and selective asorption activity against specific pathogenic substances", Key Engineering and Materials, Vols. 218-220, 175-220 (2002).

5)J-M. Wu, S. Hayakawa, K. Tsuru, A. Osaka, X.-X. Wang, "In vitro evaluation on bone-bonding of chemically modified titanium", Key Engineering and Materials, Vols. 218-220, 141-144 (2002).

6)S. Hayakawa, K. Shibata, K. Tsuru, A. Osaka, "Apatite induction on titania due to combined chemical and thermal treatments of titanium", Key Engineering and Materials, Vols. 218-220, 71-74 (2002).

7)T. Yabuta, E.P. Bescher, J.D. Mackenzie, K. Tsuru, S. Hayakawa, A. Osaka, "Synthesis of bioactive porous organic-inorganic hybrid material for biomedical application", Proceedings of the International Symposium on Bio-integrated Materials and Tissue Engineerng, pp. 73-75 (2002).

8)Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, S. Takashima, "Apatite formation and cell adhesion on silicone surface modified with gamma-Methacryloxypropyltrimethoxysilane by emulsion polymerization", Proceedings of the International Symposium on Bio-integrated Materials and Tissue Engineerng, pp. 76-78 (2002).

9)N. Azuma, A. Osaka, T. Ikoma, J. Tanaka, "The formation of multiple quality hyaluronic acid materials cross-linked with Fe(III) ion and organic acid", Proceedings of the International Symposium on Bio-integrated Materials and Tissue Engineerng, pp. 86-87 (2002).

10)T. Yoshioka, K. Tsuru, S. Hayakawa, A. Osaka, "Surface characterization and platelet adhesion of alginic acid layers on glass substrates", Proceedings of 3rd Asian International Symposium on Biomaterials and Drug Delivery Systems, pp. 222-225 (2002).

11)A. Yamada, K. Tsuru, S. Hayakawa, A. Osaka, "Chitosan-organosiloxane hybrids for biomedical applications", Proceedings of 3rd Asian International Symposium on Biomaterials and Drug Delivery Systems, pp. 279-282 (2002).

12)K. Tsuru, Y. Higashi, S. Hayakawa, A. Osaka, "Effects of organic molecules in the Kokubo's simulated body fluid on apatite formation on glass and titanium substrates", Proceedings of the 2nd Asian BioCeramics Symposium (ABC2002), pp. 81-84 (2002).

13)E. Fujii, K. Kawabata, H. Yoshimatsu, A. Osaka, Y. Miura, "Development of calcia ceramics with high hydration resistance", Proceedings of the 19th Korea-Japan International Seminar on Ceramics, pp. 480-483 (2002).

14)S. Takemoto, T. Yamamoto, K. Tsuru, S. Hayakawa, A. Osaka, S. Takashima, "Blood compatibility of titanium oxide gels on titanium substrates", Proceedings of the 19th Korea-Japan International Seminar on Ceramics, pp. 217-220 (2002).

15)K. Shibata, K. Tsuru, S. Hayakawa, A. Osaka, "Biomimetic apatite deposition on titanium substrates treated with low concentration H2O2 solutions", Bioceramics, Vol. 15, pp. 55-58 (2002).

16)Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, S. Takashima, "Cytocompatibility on silicone modified with organoalkoxysilane due to emulsion polymerization", Bioceramics, Vol. 15, pp. 687-690 (2002).

17)J.-M. Wu, K. Tsuru, S. Hayakawa, A. Osaka, "Low temperature deposition of bioactive crystalline titania films: Effects of tantalum", Bioceramics, Vol. 15, pp. 533-536 (2002).

18)F. Xiao, K. Tsuru, S. Hayakawa, A. Osaka, "Low temperature synthesis of bioactive titania thin films by two-step treatment", Bioceramics, Vol. 15, pp. 537-540 (2002).

19)Y. Aburatani, T. Uchida, Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, "Response to osteoblastic cell of the organic-inorganic hybrids", Bioceramics, Vol. 15, pp.683-686 (2002).

20)S. Takashima, T. Yamamoto, K. Tsuru, S. Hayakawa, A. Osaka, "Deactivation of active oxygen species due to metals and their blood compatibility", Bioceramics, Vol. 15, pp.105-108 (2002).


<国際会議発表>

1)Y. Kusudo, S. Takemoto, K. Tsuru, S. Hayakawa, A. Osaka, S. Takashima, "Selective adsorption of proteins on hydroxy-carbonate apatite", The 40th Symposium on Basic Science of Ceramics International Symposium on New Wave of Ceramics for the 21st Century, Abstract 1C-12I, pp. 98-99, 2002.1.22, Osaka, Japan.

2)K. Tsuru, S. Takemoto, S. Hayakawa, A. Osaka, S. Takashima, "Platelet adhesion on oxidated titanium substrates", The 40th Symposium on Basic Science of Ceramics International Symposium on New Wave of Ceramics for the 21st Century, Abstract 1C-17I, pp. 108-109, 2002.1.22, Osaka, Japan.

3)A. Mori, N. Tomita, T. Kaneeda, K. Nagata, H. Moriya, A. Osaka, K. Kuramoto, "Wear resistence of UHMPWPE mixed with vitamin E supposing lift-off in TKA", The 48th Annual Meeting of the Orthopaedic Research Society, Poster, No. 1041111, Transactions p. 1041, 2002.2.10-12, Dallas, USA.

4)T. Yabuta, E.P. Bescher, J.D. Mackenzie, K. Tsuru, S. Hayakawa, A. Osaka, "Synthesis of bioactive porous organic-inorganic hybrid materials for biomedical application", The International Symposium on Bio-integrated Materials and Tissue Engineering, Abstract P-13, pp. 73-75, 2002.3.7, Tokyo, Japan.

5)Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, S. Takashima, "Apatite formation and cell adhesion on silicone surface modifed with gamma-methacryloxypropyltrimethoxysilane by emulsion polymerization", The International Symposium on Bio-integrated Materials and Tissue Engineering, Abstract P-14, pp. 76-78, 2002.3.7, Tokyo, Japan.

6)N. Azuma, A. Osaka, T. Ikoma, J. Tanaka, " The formation of mutiple quality hyaluronic acid materials cross-linked with Fe(II) ion and organic acid", The International Symposium on Bio-integrated Materials and Tissue Engineering, Abstract P-18, pp. 86-87, 2002.3.7, Tokyo, Japan.

7)K. Tsuru, M. Kubo, S. Hayakawa, A. Osaka, "Biomimetic apatite deposition on sol-gel derived silica gel", Materials Research Society Spring Meeting, Abstract N7.12, p.241, 2002.4.4, San Francisco, USA.

8)T. Yoshioka, K. Tsuru, S. Hayakawa, A. Osaka, "Surface characterization and platelet adhesion of aliginic acid layers on glass substrates", The 3rd Asian International Symposium on Biomaterials and Drug Delivery Systems, Abstract pp.222-225, 2002.4.15, Taipei, Taiwan.

9)A. Yamada, K. Tsuru, S. Hayakawa, A. Osaka, "Chitosan-organosiloxane hybrids for biomedical applications", The 3rd Asian International Symposium on Biomaterials and Drug Delivery Systems, Abstract pp.279-282, 2002.4.15, Taipei, Taiwan.

10)A. Mori, N. Tomita, I. Sakuramoto, A. Osaka, K. Kuramoto, "Mechanical behavior of Vitamin E-containing UHMWPE", The 28th Annual Meeting of Society for Biomaterials, Poster No. 618, p. 618, 2002.4.25-27, Tampa, USA.

11)J.M. Wu, S. Hayakawa, K. Tsuru, A. Osaka, "Preparation of anatase and rutile layers on titanium substrates in aqueous solutions and their tissue-bonding ability", The American Ceramic Society, 104th Annual Meeting & Exposition, Abstract p. 80, 2002.4.30, Missouri, USA.

12)K. Tsuru, Y. Higashi, S. Hayakawa, A. Osaka, "Effects of organic molecules in the Kokubo's simulated body fluid on apatite formation on glass and titanium substrates", The 2nd Asian BioCeramics Symposium (ABC2002), Proceedings, pp. 81-84, 2002.10.25, Gteongju, Korea.

13)N. Azuma, T. Ikoma, H. Kobayashi, A. Osaka, J. Tanaka, " The formation of multiple pore quality hyaluronic acid materials cross-linked with Fe(III) ion and organic acid", Interational Symposium on Advanced Technology ISAT-1st Nanotechnology & its Related Sciences, Proceedings, p. 71, 2002.11.7, Tokyo, Japan.

14)E. Fujii, K. Kawabata, H. Yoshimatsu, A. Osaka, Y. Miura, "Development of calcia ceramics with high hydration resistance", The 19th Korea-Japan International Seminar on Ceramics, Proceedings P-5, pp. 480-483, 2002.11.21, Soul, Korea.

15)S. Takemoto, T. Yamamoto, K. Tsuru, S. Hayakawa, A. Osaka, S. Takashima, "Blood compatibility of titanium oxide gels on titanium substrates", The 19th Korea-Japan International Seminar on Ceramics, Proceedings B-11, pp. 217-220, 2002.11.21, Soul, Korea.

16)K. Tsuru, S. Takemoto, T. Yamamoto, S. Hayakawa, A. Osaka, S. Takashima, "Blood copatibility of metal oxide layers on stainless-steel", Materials Research Society Fall Meeting, Abstract B9. p. 38, 2002.12.5, Boston, USA.

17)T. Yoshioka, K. Tsuru, S. Hayakawa, A. Osaka, "Blood compatibility of stainless-steel and titanium immobilized with alginic acid layers", Materials Research Society Fall Meeting, Avstract B9. 48, p. 38, 2002.12.5, Boston, USA.

18)A. Osaka, K. Tsuru, S. Hayakawa, "Synthesis of bioactive and porous organic-inorganic hybrids for biomedical applications", The 15th International Symposium on Ceramics in Medicine, Bioceramics15, 2002.12.5, Sydney, Australia.

19)K. Shibata, K. Tsuru, S. Hayakawa, A. Osaka, "Biomimetic apatite deposition on titanium substrates treated with low concentration H2O2 solutions", The 15th International Symposium on Ceramics in Medicine, Bioceramics15, pp. 55-58, 2002.12.5, Sydney, Australia.

20)S. Takashima, T. Yamamoto, K. Tsuru, S. Hayakawa, A. Osaka, "Deactivation of active oxygen speices due to metals and their blood compatibility", The 15th International Symposium on Ceramics in Medicine, Bioceramics15, pp. 105-107, 2002.12.5, Sydney, Australia.

21)Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, S. Takashima, "Cytocompatibility on silicone modified with organoalkoxysilane due to emulsion polymerization", The 15th International Symposium on Ceramics in Medicine, Bioceramics15, pp.687-690, 2002.12.5, Sydney, Australia.

22)J.-M. Wu, K. Tsuru, S. Hayakawa, A. Osaka, "Low temperature deposition of bioactive crystalline titania films: effects of tantalum", The 15th International Symposium on Ceramics in Medicine, Bioceramics15, pp. 533-536, 2002.12.5, Sydney, Australia.

23)F. Xiao, K. Tsuru, S. Hayakawa, A. Osaka, "Low temperature synthesis of bioactive titania thin films two-step treatment", The 15th International Symposium on Ceramics in Medicine, Bioceramics15, pp. 537-540, 2002.12.5, Sydney, Australia.

24)Y. Aburatani, T. Uchida, Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, "Response to osteoblastic cell of the organic-inorganic hybrids", The 15th International Symposium on Ceramics in Medicine, Bioceramics15, pp. 683-686, 2002.12.5, Sydney, Australia.


<国内会議発表>

1)都留寛治,早川 聡,尾坂明義, "酸化処理した金属チタンの血小板吸着",「平成13年度産学官連携セミナー」,2002年2月15日,岡山市(岡山工業技術センター)

2)楠戸ゆう子,武本真治,都留寛治,早川聡,尾坂明義,高島征助,"炭酸含有ヒドロキシアパタイトを用いた血中病因タンパクの選択的吸着", 日本セラミックス協会2002年年会予稿集,講演番号1H-33, 85頁, 2002年3月25日,大阪市( 関西大学千里山キャンパス )

3)山本竜大,武本真治,都留寛治,早川聡,尾坂明義,高島征助,"熱酸化または化学酸化した金属Ti基板の抗血栓性", 日本セラミックス協会2002年年会予稿集,講演番号1H-36, 86頁, 2002年3月25日,大阪市( 関西大学千里山キャンパス )

4)藤井英司,武本真治,都留寛治,早川聡,尾坂明義,高島征助,"フッ化物イオンを含むケイ酸塩ガラスのバイオミネラリゼーション", 日本セラミックス協会2002年年会予稿集,講演番号2F-25, 221頁, 2002年3月25日,大阪市( 関西大学千里山キャンパス )

5)都留寛治,武本真治,山本竜大,早川聡,尾坂明義,高島征助,"金属酸化物層の血液適合性", 日本セラミックス協会支部連合学術講演会予稿集,講演番号A7,16-18頁, 2002年9月20日,大阪市(メルパルク大阪)

6)薮田武史,都留寛治,早川聡,尾坂明義,E.P. Bescher, J.D. Mackenzie, "多孔質Ormosil型ハイブリッドのin vitro生体適合性", 日本セラミックス協会第15回秋季シンポジウム予稿集,講演番号1B-22,11頁,2002年9月22日,秋田市(秋田大学)

7)川崎秀一,城崎由紀,都留寛治,早川聡,尾坂明義,"酸化処理した金属チタンのin vitro生体適合性評価", 日本セラミックス協会第15回秋季シンポジウム予稿集,講演番号1B-23,11頁,2002年9月22日,秋田市(秋田大学)

8)都留寛治,薮田武史,早川聡,尾坂明義,"TEOS-PDMS型多孔質ナノハイブリッドの生体活性", 高分子学会第51回高分子討論会予稿集,講演番号IIIH06, 2251-2252頁,2002年10月4日,北九州市(九州工業大学戸畑キャンパス)

9)吉岡朋彦,都留寛治,早川聡,尾坂明義,"アルギン酸を固定化した金属の血液適合性", 第24回日本バイオマテリアル学会大会講演予稿集,講演番号B2-01, 138頁, 2002年11月29日,新宿区(早稲田大学国際会議場)

10)城崎由紀,山田彩,都留寛治,早川聡,尾坂明義,"天然高分子-無機複合体の細胞適合性評価", 第24回日本バイオマテリアル学会大会講演予稿集,講演番号B2-03, 140頁, 2002年11月29日,新宿区(早稲田大学国際会議場)

11)油谷康,都留寛治,早川聡,尾坂明義,"有機-無機ハイブリッド材料の骨芽細胞様細胞に対する適合性", 第24回日本バイオマテリアル学会大会講演予稿集,講演番号B2-07, 144頁, 2002年11月29日,新宿区(早稲田大学国際会議場)

12)東紀史,生駒俊之,小林尚俊,尾坂明義,田中順三,"The Formation of homogeneous hyaluronic acid gels cross-linked with Fe(III) ion and organic acid", 第24回日本バイオマテリアル学会大会講演予稿集,183頁, 2002年11月29日,新宿区(早稲田大学国際会議場)

13)勝瑞哲也,山本竜大,都留寛治,早川聡,尾坂明義,高島征助,"チタン酸化物層の血液適合性", 第9回ヤングセラミスト・ミーティングin中四国講演予稿集,講演番号A1,1-3頁,2002年12月7日,岡山市(岡山理科大学)

14)吉岡朋彦,都留寛治,早川聡,尾坂明義,"天然高分子を固定化した金属の血液適合性", 日本セラミックス教会第6回生体関連セラミックス討論会予稿集,講演番号I-19,19頁,2002年12月12日,大阪市(テイジンホール)

15)柴田浩一,都留寛治,早川聡,尾坂明義,"H2O2処理による金属チタン表面の酸化総形成機構", 日本セラミックス教会第6回生体関連セラミックス討論会予稿集,講演番号I-24,24頁,2002年12月12日,大阪市(テイジンホール)

16)尾坂明義,"無機材料の血液適合性", 第3回全国VBL フォーラム VBL FORUM 2002「大学からのハイテクベンチャー」予稿集,204-205頁, 2002年12月20日,広島市(広島国際会議場)